The purpose of the present research work was to develop ointment of Zaltoprofen with decreased systemic side effects and to create a more marked effect with lower doses of the drug. Ointment was developed using different bases like hydrocarbon bases, Absorption bases, and others exicipients. The ointment was prepared by simple fusion method in which the drug dissolve in ointment base. The ointment was evaluated for their physical appearance, pH evaluation, spreadability, viscosity, extruability, drug content, in-vitro permeation study and accelerated stability study (As per ICH guideline). Trial and error approach was used developing eighteen batches and finally six experimental batches were formulated and evaluated on the basis of physical parameters like (appearance, pH evaluation, spreadability, rheological study, drug content, in-vitro permeation study. No drug-excipients interaction was found. These ointment formulations showed acceptable physicochemical properties. In-vitro drug permeation studies were carried out using Franz diffusion cell for 6 experimental formulations (F1-F6). Results of all six batches showed that F2 batch was selected as optimized batch with desired pH (7.1), optimum viscosity (2585.5cps) and higher % drug release (85.12%). The stability study of F2 was carried out for 1 month. The result showed that there was no significant change in the ointment properties. The optimized formulations (F2) showed acceptable pH, good visual appearance, optimum viscosity, good spreadability, extruability, drug content uniformity and highest drug permeation as compared to other formulations. The optimized formulation was subjected to accelerated stability studies as per ICH guidelines and was concluded as a stable formulation.
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